ABSTRACT
Introducción. El carcinoma de Merkel es un tumor maligno poco frecuente, que afecta principalmente a la población caucásica y cuya etiología guarda relación con el poliomavirus de las células de Merkel. Conlleva mal pronóstico, especialmente en estadios finales. Caso clínico. Se expone el caso de una paciente que presentaba un tumor primario facial de grandes dimensiones, con avanzado grado de extensión, afectación linfática cervical y metástasis parotídea derecha. Fue tratada mediante exéresis de la lesión primaria y cobertura con injerto de piel parcial, linfadenectomía cervical y parotidectomía ipsilateral. Resultados. Se logró mejoría importante en la calidad de vida de la paciente y sobrevida de al menos seis meses. Conclusión. Aunque no está claro el manejo óptimo del carcinoma de Merkel avanzado debido a su mal pronóstico, la cirugía favorece una mejoría en la calidad de vida del paciente y puede tener un papel clave en el manejo del carcinoma de Merkel en los estadios avanzados.
Introduction. Merkel carcinoma is a rare malignant tumor that mainly affects the Caucasian population and whose etiology is related to the Merkel cell polyomavirus. It has a poor prognosis, especially in the final stages. Clinical case. The case of a patient who presented a large primary facial tumor, with an advanced degree of extension, cervical lymphatic involvement and right parotid metastasis is described. She was treated surgically by excision of the primary lesion and coverage with partial skin graft, cervical lymphadenectomy, and ipsilateral parotidectomy. Results. A significant improvement was achieved in the patient's quality of life and survival of at least six months.Conclusion. Although the optimal management of advanced Merkel carcinoma is unclear due to its poor prognosis, surgery improves the patient's quality of life and it can play a key role in the management of Merkel carcinoma in advanced stages.
Subject(s)
Humans , Carcinoma, Merkel Cell , Skin Transplantation , Surgery, Plastic , Carcinoma, Neuroendocrine , Head and Neck NeoplasmsABSTRACT
OBJECTIVE: We present a case of eosinophilic pustular folliculitis, a rare dermatosis which is often associated with HIV infection or internal malignancies. CLINICAL PRESENTATION AND INTERVENTION: We report the case of a 66-year-old man with a medical history of hypertension. Histopathological examination showed a dense follicular inflammatory infiltrate with abundant eosinophils. The clinical response to indomethacin was excellent with no recurrence during the follow-up. CONCLUSION: The patient responded well to indomethacin treatment.
Subject(s)
Eosinophilia/diagnosis , Folliculitis/diagnosis , Skin Diseases, Vesiculobullous/diagnosis , Aged , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Eosinophilia/drug therapy , Eosinophilia/etiology , Folliculitis/drug therapy , Folliculitis/etiology , Humans , Immunocompetence , Indomethacin/therapeutic use , Male , Skin Diseases, Vesiculobullous/drug therapy , Skin Diseases, Vesiculobullous/etiologySubject(s)
Histiocytoma, Benign Fibrous/pathology , Skin Neoplasms/pathology , Abdomen , Humans , Male , Middle AgedSubject(s)
Psoriasis/diagnosis , Psoriasis/etiology , Tattooing/adverse effects , Adolescent , Humans , Male , Psoriasis/therapyABSTRACT
We report an unusual case of hemangiopericytoma-like dermatofibroma in the right shoulder of an 82-year-old patient with a well-defined nodular growth located in the dermis. Microscopic study revealed a band of haphazardly arranged cells with a vascular component of gaping, simple, endothelial-lined vascular structures with intervening postcapillary venules and capillary-sized slit-like "staghorn" vascular channels filled with erythrocytes; abundant mast cells were also observed. The neoplasm cells were positive for CD68 and Factor XIIIA and negative for CD34. Few data have been published on the presence of abundant mast cells (tryptase and CD117 positive) in these neoplasm. The differential diagnosis of this entity should consider other spindle cell neoplasm, including hemangiopericytoma/solitary fibrous tumor, dermatofibrosarcoma protuberans, myopericytoma, angioleiomyoma, amelanotic melanoma, pecoma, and benign and malignant peripheral nerve tumors. We present an infrequent case of dermatofibroma with a vascular pattern resembling hemangiopericytoma and the presence of abundant mast cells, which may be responsible for this vascular component.
Subject(s)
Hemangiopericytoma/pathology , Histiocytoma, Benign Fibrous/pathology , Mast Cells/pathology , Skin Neoplasms/pathology , Aged, 80 and over , Angiomyoma/diagnosis , Antigens, CD/metabolism , Antigens, Differentiation, Myelomonocytic/metabolism , Biomarkers, Tumor/metabolism , Dermatofibrosarcoma/diagnosis , Diagnosis, Differential , Factor XIIIa/metabolism , Hemangiopericytoma/metabolism , Hemangiopericytoma/surgery , Histiocytoma, Benign Fibrous/metabolism , Histiocytoma, Benign Fibrous/surgery , Humans , Male , Mast Cells/metabolism , Melanoma, Amelanotic/diagnosis , Peripheral Nervous System Neoplasms/diagnosis , Perivascular Epithelioid Cell Neoplasms/diagnosis , Skin Neoplasms/metabolism , Skin Neoplasms/surgery , Solitary Fibrous Tumors/diagnosis , Treatment OutcomeABSTRACT
A healthy, 34-year-old male presented with a 1-year history of an exophytic lesion on the leg during. On physical examination there was a 2 cm x 3 cm diameter nodule with pinkish, crusted ulceration on its surface; it was attached to skin by a pedicle. It had grown rapidly in the last month. After surgical excision the histological study confirmed the diagnosis of a polypoid dermatofibroma.
